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Is the highest-titer clone always the best production strain? In our latest #casestudy, several promising VHH expressing clones were carried forward into process-relevant evaluation. The result: clone ranking changed under more controlled conditions. The key takeaway: microscale screening identifies the most promising candidate pool, while process-relevant confirmation helps determine which candidate is best suited as the final production strain. Read the latest edition of PICHIA UNLOCKED for the full case study and key findings. #PichiaPastoris #StrainDevelopment #ProteinExpression #BioprocessDevelopment

We support teams developing recombinant peptide and protein production processes in maximizing yields, enabling robust scale-up, and achieving cost-efficient manufacturing. Our proprietary UNLOCK PICHIA® platform, based on Pichia pastoris, covers the full workflow, from early screening and protein supply to strain engineering and scalable process development. This includes methanol-induced, methanol-free, and ARMs-free expression strategies. If you're currently looking at expression systems, or want to optimize an existing strain and process, our expertise and technology in microbial protein production may be the help you need. Contact us: www.validogen.com

From early expression feasibility to scalable Pichia bioprocesses. Leveraging more than 15 years of dedicated Pichia pastoris expertise, VALIDOGEN has achieved protein titers of up to 45 g/L, up to 5-fold titer improvements through process optimization, and successful implementation of production processes at manufacturing scales of up to 200,000 L. Contact us: www.validogen.com

Scaling recombinant protein production requires more than high expression levels - it requires scalable, robust processes that consistently deliver performance at production scale. Leveraging more than 15 years of dedicated Pichia pastoris expertise, VALIDOGEN has achieved protein titers of up to 45 g/L, up to 5-fold titer improvements through process optimization, and successful implementation of production processes at manufacturing scales of up to 200,000 L. Contact us: www.validogen.com

Pichia is a powerful host for recombinant protein expression. But to achieve high titers for commercialisation you need more than just a basic plug-and-play set-up. Iskandar Dib, Principal Scientist at VALIDOGEN, explores how protein biology, secretion efficiency, promoter tuning, and process engineering determine success in scalable Pichia protein production.