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Map Ciliary Subdomains at Nanoscopic Resolution Ciliary structures—tip, pocket, membrane, basal body—operate at scales of just hundreds of nanometers, making their true protein composition difficult to resolve with conventional methods. With Syncell Microscoop® + Synlight-Pure, researchers can perform ~25 nm precision photo-biotinylation to label proteins directly from defined ciliary subdomains in situ, followed by mass spectrometry. Resolve compartment-specific proteomes, identify changes across ciliopathies, and uncover localized signaling and trafficking within primary cilia. Discover how to explore the nanoscale proteome of cilia: https://lnkd.in/guni899Q

Unlock Organ-Specific Ciliary Proteomes with Minimal Input Primary cilia vary across organs and even within tissues, but studying their proteomes is often limited by sample availability. With Syncell Microscoop® and the Thermo Fisher Astral MS, researchers can perform microscopy-guided, high-sensitivity proteomics from precise regions of interest—enabling deep, unbiased ciliary profiling from minimal tissue. Isolate and compare cilia across organs or tissue zones, capture native in situ proteomes, and uncover novel regulators and signaling pathways. Explore how this approach advances ciliary biology https://lnkd.in/gRZnTTaY

Profiling the Proteome of Primary Cilia Primary cilia play essential roles in signaling and disease, but their tiny size makes isolation difficult without disrupting their native state. Using Syncell Microscoop®, automated microscopy-guided photo-biotinylation enables spatial protein purification of thousands of primary cilia directly in situ. Combined with mass spectrometry, this approach reveals precise ciliary proteomes from cultured cells, tissues, and patient FFPE samples while minimizing antibody bias and cloning artifacts. Explore our new dataset demonstrating nanoscopic proteomics of intact ciliary structures. https://lnkd.in/gdha3zCC

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