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Purdue cancer researchers have developed a next-generation platform designed to streamline and accelerate early-stage drug discovery. 🔗 https://lnkd.in/gTeAeKnK

Purdue Institute for Cancer Research members Shawna Klahn and Nikolaos Dervisis are pioneering minimally invasive ablation protocols using focused ultrasound and pulsed electric fields, investigating their potential to enhance treatment precision and outcomes in comparative oncology. Their work could inform new therapeutic strategies for both canine and human cancers. https://lnkd.in/gqxABd2f

Purdue researchers, including Nicolás Morato and R. Graham Cooks, have developed a next-generation platform that integrates chemical synthesis, biological testing, and mass spectrometry into a single automated workflow, accelerating early-stage drug discovery, including the search for new cancer therapies. Published in PNAS, the work reflects more than a decade of development built on Purdue's pioneering DESI-MS technology. The project was supported by The National Institutes of Health's National Center for Advancing Translational Sciences (NCATS) through its ASPIRE program. 🗞️ Read the full story: https://lnkd.in/gyFnqY2u 🔬 Explore the research: https://lnkd.in/gEcw_PEK #Cancer #Research #Purdue #Science #Chemistry #tech #innovation #technology #MassSpectrometry | Purdue Science | Purdue Chemistry | Purdue Innovates | Purdue Research Foundation

From fundamental insight to real-world impact for nearly 50 years.

The National Cancer Institute has renewed Purdue's Cancer Center Support Grant, reinforcing nearly 50 years of cancer research leadership. The Purdue Institute for Cancer Research is one of only eight NCI-designated Basic Laboratory Cancer Centers in the nation and one of only two located at a public university.

A team of Purdue researchers led by Purdue Institute for Cancer Research (PICR) member Graham Cooks has developed a method that uses fast-moving microdroplets to accelerate chemical reactions without high temperatures or catalysts. “These reactions proceed up to a million times faster than those in a bulk solution,” according to Nicolás Morato, research assistant professor at PICR and a member of Aston Labs. “We are using this capability to rapidly synthesize libraries of chemicals that can be used to develop a variety of drugs, such as cancer treatments and antibiotics, as well as agricultural materials that protect crops. The same DESI system can also be used to test these chemicals’ activities right after creating them. We can generate thousands of anticancer drug candidates and test how well they work against a cancer-related enzyme, or even directly in cancer cells, all using the same technology.” 🗞️ Catch the FULL STORY: https://lnkd.in/gMjni9wQ #Purdue #Cancer #Science #Chemistry #BoilerUp #Research #Innovation