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Cancer creates environments that are difficult to penetrate, suppress immune responses, and frequently give rise to resistance. Could microorganisms offer a different way forward? In this blog article, discover what makes engineered bacteria and viruses uniquely suited to some of oncology's most complex challenges. Read to learn more about: 🔹 Why tumors can be uniquely permissive to microorganisms 🔹 How engineered bacteria and viruses interact with complex tumors 🔹 Why microbial therapies require a different approach to preclinical evaluation #CancerResearch #ImmunoOncology #Biotechnology

Radiopharmaceuticals combine powerful tumor-killing potential with exceptional specificity. However, strong binding alone does not make a targeting molecule a suitable radiopharmaceutical candidate. Pretargeting separates the targeting molecule from radionuclide delivery, relaxing the tight pharmacokinetic requirements of conventional radiopharmaceutical development. This can open the door to promising candidates with otherwise unsuitable PK profiles, including larger molecules such as antibody-based targeting vectors. In this blog article, discover: 🔹How pretargeting works, 🔹The advantages and constraints of the strategy, 🔹When a pretargeting approach makes sense. 🔗Look at our webinar replay: https://lnkd.in/d9KTrA6C 🔗Grab our free ebook: https://lnkd.in/dD4Uahdc #Radiopharmaceutical #PreclinicalResearch

Radiopharmaceuticals combine powerful tumor-killing potential with exceptional specificity. However, strong binding alone does not make a targeting molecule a suitable radiopharmaceutical candidate. Pretargeting separates the targeting molecule from radionuclide delivery, relaxing the tight pharmacokinetic requirements of conventional radiopharmaceutical development. This can open the door to promising candidates with otherwise unsuitable PK profiles, including larger molecules such as antibody-based targeting vectors. In this blog article, discover: 🔹How pretargeting works, 🔹The advantages and constraints of the strategy, 🔹When a pretargeting approach makes sense. 🔗Look at our webinar replay: https://lnkd.in/d9KTrA6C 🔗Grab our free ebook: https://lnkd.in/dD4Uahdc #Radiopharmaceutical #PreclinicalResearch

Lung function is a key criterion in clinical trials for the evaluation of new pulmonary fibrosis therapies, similarly to other respiratory diseases. How we test lung function efficacy during the preclinical phase is therefore an important aspect of a candidate's critical path. In this blog article we evaluate case study data comparing pathological and functional efficacy indicators in pulmonary fibrosis models for an ALK5 inhibitor. Read about: ● The difference between preclinical endpoints and clinical outcomes ● Histological assessment of an ALK5 inhibitor with strong biological activity ● Functional assessment, comparisons and correlations for an ALK5 inhibitor ● Selecting endpoints for preclinical pulmonary fibrosis studies ● Key takeaways #PreclinicalResearch #Fibrosis #PulmonaryFibrosis

Pruritus, or itch, is one of the most burdensome symptoms experienced by patients with inflammatory skin diseases such as atopic dermatitis or psoriasis. It is also a primary outcome and key measurement of efficacy in clinical trials. A compound that demonstrates great preclinical biology does not necessarily offer substantial pruritus relief. In this recently published case study, we compare biological readouts and functional readouts for a topical corticosteroid, reviewing: • Experimental set-up • Model selection criteria • Study data • Conclusions • Key takeaways Expand your knowledge about how functional scratching studies can help build a more complete assessment of patient-centric therapeutic efficacy, enabling an early snapshot of itch relief that can impact confidence in a compound and de-risk progression into human trials.

Pruritus, or itch, is one of the most burdensome symptoms experienced by patients with inflammatory skin diseases such as atopic dermatitis or psoriasis. It is also a primary outcome and key measurement of efficacy in clinical trials. A compound that demonstrates great preclinical biology does not necessarily offer substantial pruritus relief. In this recently published case study, we compare biological readouts and functional readouts for a topical corticosteroid, reviewing: • Experimental set-up • Model selection criteria • Study data • Conclusions • Key takeaways Expand your knowledge about how functional scratching studies can help build a more complete assessment of patient-centric therapeutic efficacy, enabling an early snapshot of itch relief that can impact confidence in a compound and de-risk progression into human trials.