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Physiological stress is linked to skin aging, hair greying, and hair loss, but its direct effects are poorly understood because relevant human models are lacking. Hair-bearing human skin organoids reproduce the main structures of native skin, including the epidermis, dermis, hair follicles, and melanocytes. In this study, we cultured hiPSC-derived skin organoids for 60–100 days and then treated them with 100 µM norepinephrine for about two months to model stress-induced hair greying. Norepinephrine reduced KRT10 and Collagen I, cut PMEL expression by 70% and SOX2 by about 50%, and turned hair from black to grey. This points to disruption of the dermal papilla niche in the hair follicle. The results show that skin organoids are a realistic platform for studying stress-related skin and hair changes and for testing cosmetic ingredients. 🎬 Watch the full presentation: https://lnkd.in/g7dCy-P6 📩 Discuss your study: [email protected] #organoids #dermatology #skinorganoid #cosmetics #skinbiology

🚀 Our team is heading to Perth - 5 days to go for IFSCC 2026! IFSCC International Federation of Societies of Cosmetic Chemists A glimpse into our hair follicle organoid platform: this time-lapse video captures changes in hair growth following treatment with a test candidate. By tracking measurable hair growth responses in a human-relevant 3D model, the platform can support the evaluation and comparison of candidate compounds for hair-related applications. 📍 Meet Lambda Biologics at IFSCC 2026, Perth 📅 Sep 29 – Oct 1 📌 Booth #013 📩 Book a meeting: https://lnkd.in/g4jx9pZT Let’s discuss how human skin & hair organoids can support your dermatology and cosmetic research. #LambdaBiologics #IFSCC2026 #SkinOrganoid #HairFollicle #HairResearch #CosmeticResearch #Dermatology #Organoids IFSCC Congress

In dermatology and cosmetic R&D, promising in vitro activity is not enough. The real question is: will the effect translate to human skin? Human #SkinOrganoids provide a physiologically relevant 3D model for evaluating active ingredients and therapeutic candidates directly in human tissue - helping researchers generate more meaningful efficacy data and prioritize promising candidates earlier. At Lambda Biologics, our Preclinical Skin Organoid Screening Services provide a standardized screening platform using pre-cultured, mature 3D human skin organoids. What can you evaluate? ✅ Human-relevant efficacy: Assess candidate responses in 3D tissue that reproduces key structural features of human skin, including a stratified epidermis and functional dermal compartment. ✅ Quantifiable skin & hair endpoints: Monitor morphological and biological responses, including hair bulb formation and visible pigmented hair sprouting through bright-field imaging. ✅ Animal-free testing: Generate efficacy data using human-derived models while reducing reliance on conventional animal testing. ✅ Candidate comparison & screening: Evaluate multiple ingredients, compounds, or formulations under standardized experimental conditions to identify candidates worth advancing. For cosmetic ingredients, hair-growth candidates, and dermatological therapeutics, the goal is not simply to generate more preclinical data, it is to generate data that better reflects human biology. 📍 Meet Lambda Biologics at IFSCC 2026 September 29–October 1 | Booth #013 Visit us to explore how skin organoid models can support your next efficacy study, or contact our team to request the service brochure and discuss your research. #SkinOrganoids #CosmeticResearch #DermatologyResearch #CosmeticScience #PreclinicalScreening #AnimalFreeScience #IFSCC2026 #Lambdabiologics

🧬 More than an organoid model. A CRC organoid bank built for translational research. Colorectal cancer is a highly heterogeneous disease, requiring models that accurately reflect the diversity of patient tumors. Our CRC organoid bank comprises genomically characterized, patient-derived organoids that enable mutation-specific model selection for drug testing, biomarker discovery, mechanism-of-action studies, and resistance research. To further enable precision oncology applications, drug sensitivity data have been generated across a growing collection of CRC organoid lines using standard-of-care therapies including 5-FU (#Fluorouracil), #Oxaliplatin, and #Irinotecan. These data help researchers select organoids best suited to evaluate investigational therapies and understand mutation-driven drug responses. 👉 See more: https://lnkd.in/gYVZCXBW From genomic profiling to functional validation, our CRC organoid bank provides a powerful platform for drug discovery, translational research, and the development of personalized cancer therapies. #ColorectalCancer #CRC #CancerOrganoids #PrecisionOncology #DrugDiscovery #TranslationalResearch #Organoids #WES #Biobank #PDO

𝐓𝐚𝐫𝐠𝐞𝐭 𝐞𝐱𝐩𝐫𝐞𝐬𝐬𝐢𝐨𝐧 𝐢𝐬 𝐨𝐧𝐥𝐲 𝐨𝐧𝐞 𝐥𝐚𝐲𝐞𝐫. 𝐒𝐩𝐚𝐭𝐢𝐚𝐥 𝐜𝐨𝐧𝐭𝐞𝐱𝐭 𝐝𝐞𝐭𝐞𝐫𝐦𝐢𝐧𝐞𝐬 #𝐀𝐃𝐂 𝐫𝐞𝐥𝐞𝐯𝐚𝐧𝐜𝐞. For an antibody-drug conjugate to succeed, researchers need to understand more than whether the target is present. ❓Key questions include: • Is the target expressed across heterogeneous tumor regions? • Is the target also expressed in surrounding normal tissue? • How are immune cells distributed within the tumor microenvironment? • How do these spatial relationships influence efficacy and safety? When combined with Lambda Biologics’ #organoid-based ADC evaluation platform, #spatialbiology can provide complementary tissue-level insight to support more human-relevant assessment of ADC efficacy, toxicity, and translational potential. 🔗 Contact us to discuss your ADC spatial biology study: https://lnkd.in/g84TbhKV #AntibodyDrugConjugates #PhenoCycler #Organoids #TumorMicroenvironment #TME #CancerResearch #PrecisionOncology #DrugDiscovery #PreclinicalResearch #TranslationalResearch #LambdaBiologics

A new first-line option has just arrived for HER2+ #gastric #cancer. But even within a biomarker-defined population, not every tumor behaves the same. The FDA approval (on August 25) of zanidatamab-containing regimens highlights the continuing evolution of targeted treatment for HER2+ gastroesophageal cancer. Yet #gastric #cancer remains highly heterogeneous. Differences in patient-specific tumor biology and the tumor microenvironment (#TME) can influence drug sensitivity, immune response, and treatment resistance. #Patientderived gastric cancer organoids can help bring this complexity into preclinical evaluation, enabling functional drug-response profiling across diverse patient models and, with stromal or immune co-culture, more TME-relevant testing. Lambda Biologics's patient-derived gastric cancer organoids are available through our biobank, providing a diverse panel of patient-relevant models for drug-response profiling and translational research. 💬 Contact us to discuss your study with Organoid: [email protected] #Lambdabiologics #GastricCancer #HER2 #Organoids #TumorMicroenvironment #DrugDiscovery #TranslationalResearch