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The latest issue of JACC features Dr. Milton Packer’s exploration of the “adipokine hypothesis,” a framework linking adipocyte biology to HFpEF. Along with expert commentaries, the issue also debuts an interactive adipokine tool that lets readers explore molecular roles in HFpEF.

The latest clinical practice guideline from the ACC and AHA, along with 11 other societies, provides updated recommendations for clinicians on the prevention, detection, evaluation, and management of high blood pressure in adults. Published in JACC, the new guideline reflects the latest research and evidence since February 2015 and replaces the previous version from 2017.

Beyond Information Asymmetry in Medicine Dr. Harlan Krumholz's father's patients came with questions. His arrived with printouts. His daughter's patients arrive with a plan. The doctor-patient dynamic has changed. "Search engines gave patients documents. Large language models give them an interlocutor." This is the change Dr. Krumholz describes in his Editor's Page this week in #JACC. The asymmetry of information, and even expertise, between physicians and patients is eroding, and it was once the basis of authority. The durable distinction is not between what a machine can know and what a clinician can know. It is between an answer and a relationship. "The future of expertise may be defined less by what knowledge physicians possess than by the fidelity with which they serve." That asks more of physicians, not less. Read the full editor's page here: https://bit.ly/4AJCjld

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