Standard BioTools

Can the oral microbiome influence disease throughout the body? Researchers are increasingly finding links between oral health and conditions ranging from cardiovascular disease and diabetes to Alzheimer’s disease. In our latest scientific spotlight, Morgane Ortis, PhD, shares how she and her colleagues at MICORALIS have investigated the complex interactions between bacteria, viruses and host biology that may contribute to both oral and systemic disease. Read the spotlight to learn more: https://lnkd.in/gySvyQ3h #Microbiome #Microfluidics #qPCR

A post-translational protein feature, H3K27ac, emerged as a key predictor of ADC response, revealing biology invisible to spatial transcriptomics. In a recent study of HER2-positive breast cancer treated with the ADC SHR-A1811, researchers at Fudan University found that tumors achieving a pathological complete response contained higher proportions of H3K27ac-positive epithelial cells. Because H3K27ac is a post-translational histone modification, it reflects a functional protein state that could not be directly detected through RNA expression alone. Using Imaging Mass Cytometry™ (IMC™) technology, researchers gained a more complete view of the biology associated with ADC response and resistance. Their findings showed that therapeutic response was influenced not only by tumor cell biology, but also by features of the tumor microenvironment. ➡️ H3K27ac-positive tumor cells were associated with response ➡️ Collagen-rich, fibroblast-dense microenvironments were associated with resistance ➡️ Spatial features derived from IMC were used to develop an ADC efficacy prediction model and investigate combination strategies designed to improve ADC response For ADC researchers, these findings highlight the value of looking beyond target expression alone to understand the functional states and microenvironment features that shape therapeutic efficacy. Read more in our latest article: https://lnkd.in/g7fdAQGe #ADC #AntibodyDrugConjugates #SpatialProteomics #IMC #SpatialBiology #CancerResearch #DrugDevelopment

Get the latest microfluidics updates from Standard BioTools! In this edition: • Watch our pathogen surveillance masterclass with Luke Stewart • Learn about the University of Wisconsin–Madison project using microfluidic PCR and air sampling to track respiratory pathogens in K–12 schools • Discover new research showing how temporal gene expression profiling can reveal hidden cancer biology • Read our publication digest on SNP-based molecular fingerprinting for sample identification in biobanks • Explore our APHL 2026 poster on broad-spectrum detection and subtyping of respiratory pathogens • Take our newsletter pop quiz 👉 Read the latest issue and subscribe for future updates. #Microfluidics #Genomics #PathogenSurveillance

Are you only measuring part of the immune response? Low‑expressing #cytokines such as IL‑10 and IL‑13 are difficult to detect using conventional methods. Excluding them from your panel means missing key insights into immune regulation that are essential for mechanistic and cell therapy research. In this 4‑minute brief, Anna Belkina, MD, PhD, (Boston University) explains why prioritizing easier‑to‑detect cytokines like TNFα and IFNγ captures only part of the picture and how a broader approach can reveal #functionalbiology that is often overlooked. She describes the three phases of the immune response—inflammation, resolution and homeostasis—each driven by distinct cytokines, and how a “street‑lamp” bias narrows our understanding of immune behavior. 👉 Watch the full session to explore new strategies for detecting low‑abundance cytokines: https://lnkd.in/eCHvwpk8

Regulatory T cells (Tregs) play a critical role in maintaining immune balance, but understanding their function requires new approaches to uncover rare and heterogeneous cell populations. Watch this short overview in which James Wing, PhD, from the University of Osaka, highlights how #CyTOF high‑dimensional profiling is being used to study human regulatory T cells, including specialized T follicular regulatory (Tfr) subsets involved in controlling antibody responses. The discussion explores how changes in these populations are linked to immune dysregulation in infection and disease, and why single‑cell approaches are essential for uncovering this biology: https://lnkd.in/gXPcEu76 Interested in a deeper dive? Watch the full-length masterclass for a deep dive into regulatory T cells: https://lnkd.in/g4HpyFUc #RegulatoryTCells #Tregs #TfrCells #Immunology #SingleCellAnalysis #MassCytometry #CyTOF #ImmuneRegulation

Discover how high-throughput qPCR can accelerate biomarker discovery for complex disease research. Join us for a live webinar with Barbara Breznik, PhD, Cancer Biology Group Leader at the National Institute of Biology, Slovenia, and Assistant Professor at the University of Ljubljana, to learn how her team used targeted gene expression profiling with the Biomark™ system to uncover biomarkers associated with poor prognosis and therapy resistance. Wednesday, November 19 | 08:00 PT |11:00 ET | 16:00 GMT | 17:00 CET