International Institute of Molecular and Cell Biology in Warsaw

Transgenic mouse models for academic research and rare disease studies. Some research questions require a precise genetic model. At the Genome Engineering Facility, the IN-MOL-CELL infrastructure at the International Institute of Molecular and Cell Biology in Warsaw supports researchers in developing genetically modified and transgenic mouse models using CRISPR/Cas9 technology. The facility combines molecular biology, genetic engineering and embryology expertise. Its services include consulting on custom projects, designing mutagenesis strategies, microinjections into oocytes and zygotes, genotyping, mouse breeding, initial phenotyping, sperm and embryo cryopreservation, and mouse line rederivation. These models support studies ranging from basic gene function to rare disease mechanisms and the search for potential therapeutic strategies. Learn more on the main IN-MOL-CELL website: https://lnkd.in/dwuHh_3Q IN-MOL-CELL Infrastructure is funded by the European Union - NextGenerationEU under the National Recovery and Resilience Plan. IN-MOL-CELL Infrastructure is also funded by the European Union under Horizon Europe, Project 101059801 - RACE, and by the RACE-PRIME project carried out within the IRAP programme of the Foundation for Polish Science, co-financed by the European Union under the European Funds for Smart Economy 2021-2027. #IIMCB #INMOLCELL #GenomeEngineering #CRISPRCas9 #RareDiseaseResearch #MouseModels #ResearchInfrastructure #MolecularBiology #ResearchInfrastructure #KorzyściDlaCiebie, #NextGenerationEU, #FunduszeUE

The Preclinical Drug Development Facility provides an integrated workflow from gene cloning to high-resolution protein structure determination. The facility supports protein production in bacterial, mammalian and insect expression systems, recombinant protein purification, crystallization of proteins and their complexes, X-ray data analysis, and cryo-electron microscopy from sample preparation to 3D structure. Its work helps researchers understand molecular mechanisms, support drug discovery projects and move from concept to structural insight. By combining protein production, cryo-EM, crystallography and expert consultation, the facility supports structural and functional studies across molecular and biomedical research. IN-MOL-CELL Infrastructure is funded by the European Union - NextGenerationEU under the National Recovery and Resilience Plan. IN-MOL-CELL Infrastructure is also funded by the European Union under Horizon Europe, Project 101059801 - RACE, and by the RACE-PRIME project carried out within the IRAP programme of the Foundation for Polish Science, co-financed by the European Union under the European Funds for Smart Economy 2021-2027. #IIMCB #INMOLCELL #PreclinicalDrugDevelopment #ProteinScience #StructuralBiology #CryoEM #XrayCrystallography #DrugDiscovery #MolecularBiology #ResearchInfrastructure #KorzyściDlaCiebie, #NextGenerationEU, #FunduszeUE

The Mass Spectrometry Facility supports researchers in translating complex biological samples into high-quality molecular data. The facility provides bottom-up proteomics, interactomics, consultations, data analysis and custom method development. Its advanced instrumentation enables high-resolution analysis of proteins and other biomolecules, supports studies based on limited sample material, and helps generate actionable insights for biomedical research. From experimental design to data acquisition and interpretation, the team works with researchers to build workflows adapted to the scientific question. IN-MOL-CELL Infrastructure is funded by the European Union - NextGenerationEU under the National Recovery and Resilience Plan. IN-MOL-CELL Infrastructure is also funded by the European Union under Horizon Europe, Project 101059801 - RACE, and by the RACE-PRIME project carried out within the IRAP programme of the Foundation for Polish Science, co-financed by the European Union under the European Funds for Smart Economy 2021-2027. #IIMCB #INMOLCELL #MassSpectrometry #Proteomics #Interactomics #Multiomics #MolecularBiology #ResearchInfrastructure #NextGenerationEU, #FunduszeUE

From concept to data: mass spectrometry that empowers discovery. The Mass Spectrometry Facility supports researchers in translating complex biological samples into high-quality molecular data. Before it could empower discovery, some of the Mass Spectrometry Facility’s advanced equipment first had to make a remarkable entrance — by crane. The facility provides bottom-up proteomics, interactomics, consultations, data analysis and custom method development. Its advanced instrumentation enables high-resolution analysis of proteins and other biomolecules, supports studies based on limited sample material, and helps generate actionable insights for biomedical research. From experimental design to data acquisition and interpretation, the team works with researchers to build workflows adapted to the scientific question. IN-MOL-CELL Infrastructure is funded by the European Union - NextGenerationEU under the National Recovery and Resilience Plan. IN-MOL-CELL Infrastructure is also funded by the European Union under Horizon Europe, Project 101059801 - RACE, and by the RACE-PRIME project carried out within the IRAP programme of the Foundation for Polish Science, co-financed by the European Union under the European Funds for Smart Economy 2021-2027. #IIMCB #INMOLCELL #MassSpectrometry #Proteomics #Interactomics #Multiomics #MolecularBiology #ResearchInfrastructure #KorzyściDlaCiebie, #NextGenerationEU, #FunduszeUE

The Biophysics and Bioanalytics Facility provides access to advanced methods for studying macromolecules and their complexes. Using a broad portfolio of molecular biophysics techniques, the facility helps characterize molecular size, secondary and quaternary structure, thermal and chemical stability, and intermolecular interactions. Its capabilities include analytical ultracentrifugation, dynamic light scattering with zeta potential, circular dichroism, differential scanning calorimetry, isothermal titration calorimetry, surface plasmon resonance, microscale thermophoresis and chromatography workflows. The team supports both academic and commercial users, including research and development projects and biosimilarity studies. IN-MOL-CELL Infrastructure is funded by the European Union - NextGenerationEU under the National Recovery and Resilience Plan. IN-MOL-CELL Infrastructure is also funded by the European Union under Horizon Europe, Project 101059801 - RACE, and by the RACE-PRIME project carried out within the IRAP programme of the Foundation for Polish Science, co-financed by the European Union under the European Funds for Smart Economy 2021-2027. #IIMCB #INMOLCELL #Biophysics #Bioanalytics #MolecularBiology #ProteinScience #ResearchInfrastructure #ReproducibleScience #KorzyściDlaCiebie, #NextGenerationEU, #FunduszeUE

Some of the biggest biological questions can be studied in a small vertebrate model. At the Zebrafish Core Facility, the IN-MOL-CELL infrastructure at the International Institute of Molecular and Cell Biology in Warsaw supports life science research using Danio rerio as a model organism. The facility provides high-quality zebrafish lines, controlled aquatic systems, specialized equipment and technical expertise for studies in developmental biology, genetics, neurobiology and biomedical research. Its services include breeding and maintaining zebrafish lines, providing embryos and adult fish for experiments, microinjection of zebrafish embryos, screening embryos for fluorescence signals, cryopreservation of zebrafish sperm, tissue sampling, genotyping, and fish handling and welfare training for new and experienced users. Researchers receive support from early experimental planning to project execution. The team also collaborates with research groups in Poland and abroad, sharing expertise in zebrafish breeding, care and aquatic system management, and exchanging zebrafish lines with other research centers. Explore what zebrafish can bring to your research. IN-MOL-CELL Infrastructure is funded by the European Union - NextGenerationEU under the National Recovery and Resilience Plan. IN-MOL-CELL Infrastructure is also funded by the European Union under Horizon Europe, Project 101059801 - RACE, and by the RACE-PRIME project carried out within the IRAP programme of the Foundation for Polish Science, co-financed by the European Union under the European Funds for Smart Economy 2021-2027. #IIMCB #INMOLCELL #MolecularBiology #ResearchInfrastructure #KorzyściDlaCiebie, #NextGenerationEU, #FunduszeUE