INDIGO Biosciences, INC

RORα is a therapeutic target in several conditions such as metabolic disorders, neurodegenerative diseases, and certain inflammatory conditions because it regulates genes involved in lipid metabolism, circadian rhythm, immune function, and neuroprotection. The principle application of this assay is in the screening of test samples to quantify functional activities, either agonist or antagonist, that they may exert against RAR-related Orphan Receptor Alpha. Talk to one of our scientists today about our human RORα assays!

PXR is a therapeutic target in several conditions such as drug-induced liver injury, inflammatory diseases, metabolic disorders, and certain cancers because it is a nuclear receptor that regulates the expression of genes involved in xenobiotic metabolism, drug transport, and lipid and glucose homeostasis. The principle application of this assay is in the screening of test samples to quantify functional activities, either agonist or antagonist, that they may exert against Pregnane X Receptor. Talk to one of our scientists today about our human PXR assays!

Cytochrome P450 (CYP450) enzymes are a critical component of drug metabolism, playing a key role in the biotransformation of many therapeutic agents. These enzymes are responsible for the oxidation of organic substances, impacting both drug efficacy and safety. INDIGO Biosciences is a leader in the field of drug metabolism and pharmacokinetics, specializing in CYP450 induction and inhibition studies. https://lnkd.in/evSnpdFN

AhR is a therapeutic target in several conditions such as cancer, autoimmune diseases, inflammatory disorders, and metabolic dysfunction because it functions as a ligand-activated transcription factor that regulates genes involved in xenobiotic metabolism, immune modulation, and cell differentiation. The principle application of this assay is in the screening of test samples to quantify functional activities, either agonist or antagonist, that they may exert against Aryl Hydrocarbon Receptor. Talk to one of our scientists today about our human AhR assays!

Nrf2 is a therapeutic target in several conditions such as neurodegenerative diseases, cancer, cardiovascular disorders, and inflammatory conditions, because of its role in regulating cellular defense mechanisms against oxidative stress and maintaining redox homeostasis. The principal application of this reporter assay system is in the screening of test samples to quantify functional activity, either agonist or antagonist, that may exert against Human Nrf2. Talk to one of our scientists today about our human Nrf2 assays! https://bit.ly/49xyjJa

INDIGO Biosciences provides fast, reliable in vitro hepatotoxicity screening services to help drug discovery teams identify hepatotoxic compounds before advancing them to preclinical or clinical development stages. INDIGO's hepatotoxicity assay leverages upcyte® human hepatocytes, a physiologically relevant model for predicting drug-induced liver injury (DILI). Talk to a scientist today about our Hepatotoxicity Services! https://lnkd.in/exF-xPV3