Flagship Pioneering

Flagship Pioneering has launched a new Substack: The Labs Report. The Labs Report shares early scientific progress, original data, technical breakthroughs, and perspectives from the teams working to transform human health, sustainability, and more. Subscribe for a behind-the-scenes look at pioneering science as it unfolds.

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Policymakers in DC are increasingly focused on the U.S.’ limited capacity to manufacture critical physical goods like medicines, and the threat that poses to our national and economic security. But tomorrow, in a Senate HELP Committee hearing convened under the leadership of Sen. Bill Cassidy, they will turn their attention to an even more important problem: our leadership in discovering and designing the next generation of innovative medicines is also under serious threat. In the article below, I’ve laid out a few thoughts on how we can reinforce America’s capacity to compete and win in the race for a new era of health, security, and prosperity.

While standard large language models (LLMs) can hold a decent conversation, they can tend toward sycophancy. For casual exchanges, that tendency is typically harmless. But when people turn to AI for support through the full range of life’s experiences, constant affirmation may fall short of building psychological fitness. Addressing this challenge requires AI that can do more than simply respond convincingly. Following today’s announcement of Flagship’s latest company, iris labs, we dive deep into the iris labs tam has made advances across two particularly important areas of AI: self-learning and safety. Read the full write-up on The Labs Report: https://lnkd.in/gYDwY8hc

Biology is a long-context process, but today's co-folding models can only reason over a fraction of it. LightFold, Flagship's proprietary co-folding model, was built to close that gap. Stories like this run every week on The Labs Report: early scientific progress, original data, and technical breakthroughs from across the Flagship Pioneering ecosystem of companies.