Celemics, Inc.

𝗖𝗮𝗻 𝘁𝗵𝗲 𝘀𝗮𝗺𝗲 𝗡𝗚𝗦 𝗹𝗶𝗯𝗿𝗮𝗿𝘆 𝘄𝗼𝗿𝗸𝗳𝗹𝗼𝘄 𝗱𝗲𝗹𝗶𝘃𝗲𝗿 𝗰𝗼𝗺𝗽𝗮𝗿𝗮𝗯𝗹𝗲 𝗽𝗲𝗿𝗳𝗼𝗿𝗺𝗮𝗻𝗰𝗲 𝗮𝗰𝗿𝗼𝘀𝘀 𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝘁 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗶𝗻𝗴 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺𝘀? Read the blog: https://lnkd.in/g9hnaJRz Celemics evaluated libraries prepared with its Library Preparation Kit and Custom Capture Panels on both Element Biosciences AVITI and Illumina NextSeq 500 using the same analysis pipeline. The results showed comparable sequencing performance between the two platforms across both panels tested. For laboratories considering multiple sequencing platforms, this means the same Celemics library preparation workflow can be applied to both AVITI and Illumina—without maintaining separate preparation workflows. Explore the full comparison and detailed results in our latest blog and Application Note. View the Application Note: https://lnkd.in/g4c9gJX8 #ngs #elementbiosciences #AVITI #illumina #librarypreparation #targetcapture #sequencing #celemics

𝗛𝗼𝘄 𝗰𝗮𝗻 𝘃𝗶𝗿𝗮𝗹 𝗴𝗲𝗻𝗼𝗺𝗲𝘀 𝗯𝗲 𝗿𝗲𝗹𝗶𝗮𝗯𝗹𝘆 𝗱𝗲𝘁𝗲𝗰𝘁𝗲𝗱 𝘄𝗵𝗲𝗻 𝗺𝗼𝘀𝘁 𝗻𝘂𝗰𝗹𝗲𝗶𝗰 𝗮𝗰𝗶𝗱𝘀 𝗶𝗻 𝗮 𝘀𝗮𝗺𝗽𝗹𝗲 𝗮𝗿𝗲 𝗵𝗼𝘀𝘁-𝗱𝗲𝗿𝗶𝘃𝗲𝗱 𝗼𝗿 𝘀𝗲𝘃𝗲𝗿𝗲𝗹𝘆 𝗱𝗲𝗴𝗿𝗮𝗱𝗲𝗱? (🔗https://lnkd.in/gm8gxW5V) Environmental and animal-derived samples often present significant challenges for viral NGS. High host background can reduce the proportion of informative viral reads, while heat treatment, lyophilization, and natural degradation can lead to extensive RNA fragmentation. Our latest blog explores how Viral Target Capture can support viral genome analysis in these challenging sample types, including: • Adventitious virus detection • High-Ct, wildlife-derived Influenza A samples • Avian Influenza H5 detection in wastewater samples The validation results demonstrate how targeted enrichment can improve the recovery of viral genomic data while reducing the impact of high host background and sample degradation. #viralngs #targetcapture #pathogengenomics #animalhealth #wastewatersurveillance #avianInfluenza #wholegenomesequencing #celemics

𝗪𝗵𝗮𝘁 𝗱𝗲𝘁𝗲𝗿𝗺𝗶𝗻𝗲𝘀 𝘁𝗵𝗲 𝗽𝗲𝗿𝗳𝗼𝗿𝗺𝗮𝗻𝗰𝗲 𝗼𝗳 𝗮 𝘁𝗮𝗿𝗴𝗲𝘁𝗲𝗱 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗶𝗻𝗴 𝗽𝗮𝗻𝗲𝗹? 🔗 Read more: https://lnkd.in/gutMCd8Y Probe design is one of the fundamental factors influencing target enrichment performance. But effective design involves more than simply covering the target regions. In our latest blog, Celemics shares how RNA probes, 2X tiling, probe modifications, and rebalancing based on actual wet-lab data are incorporated into its panel design approach. We also discuss why panel performance should be evaluated transparently including regions that are inherently difficult to capture rather than simply excluding them from performance metrics. #ngs #probedesign #targetenrichment #targetedsequencing #hybridcapture #celemics

𝗣𝗖𝗥 𝗶𝘀 𝗻𝗼𝘁 𝗲𝗻𝗼𝘂𝗴𝗵 — 𝗴𝗼 𝗳𝘂𝗿𝘁𝗵𝗲𝗿 𝘄𝗶𝘁𝗵 𝗛𝗮𝗻𝘁𝗮𝘃𝗶𝗿𝘂𝘀 𝘄𝗵𝗼𝗹𝗲-𝗴𝗲𝗻𝗼𝗺𝗲 𝗡𝗚𝗦. Read more: https://lnkd.in/dEaZ3NWf As genomic surveillance becomes increasingly important for emerging infectious diseases, whole-genome analysis is critical for variant tracking, phylogenetic analysis, and outbreak investigation. In our latest blog, we share validation data generated using the Celemics Hemorrhagic Fever Syndrome Panel applied to Hantaan virus clinical specimens. Key highlights: • ≥95% 10x whole-genome coverage at Ct 30.9 • Stable performance in low viral load clinical samples • Simultaneous analysis of 10 Hantavirus species • Species-specific blocker technology for improved enrichment efficiency Explore how NGS-based target enrichment enables reliable pathogen genomics beyond conventional PCR-based detection. #ngs #hantavirus #pathogengenomics #genomicsurveillance #targetenrichment #wholegenomesequencing #infectiousdisease

𝗪𝗵𝘆 𝗱𝗼𝗲𝘀 𝗔𝗱𝗮𝗽𝘁𝗶𝘃𝗲 𝗦𝗮𝗺𝗽𝗹𝗶𝗻𝗴 𝘀𝘁𝗶𝗹𝗹 𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗲 𝘀𝗶𝗴𝗻𝗶𝗳𝗶𝗰𝗮𝗻𝘁 𝗼𝗳𝗳-𝘁𝗮𝗿𝗴𝗲𝘁 𝗱𝗮𝘁𝗮? Read more: [https://lnkd.in/dinzSyiK] In Native DNA + Adaptive Sampling workflows, sequencing pores spend substantial resources rejecting non-target reads because the absolute proportion of target DNA remains low. Our latest blog explores how combining Hybrid Target Enrichment with ONT Adaptive Sampling changes sequencing efficiency by increasing target density before sequencing begins. 𝗞𝗲𝘆 𝗼𝗯𝘀𝗲𝗿𝘃𝗮𝘁𝗶𝗼𝗻𝘀: • Up to 96% on-target ratio with TE + AS • Reduced uncovered regions across multiple cancer panels • Higher mean depth coverage compared to conventional workflows • Improved sequencing resource utilization for small target panels Rather than replacing Target Enrichment, Adaptive Sampling becomes significantly more effective when combined with optimized enrichment workflows. #ngs #longreadsequencing #oxfordnanopore #adaptivesampling

𝗜𝗳 𝗣𝗖𝗥 𝗮𝗺𝗽𝗹𝗶𝗰𝗼𝗻 𝘀𝗲𝗾𝘂𝗲𝗻𝗰𝗶𝗻𝗴 𝗮𝗹𝗿𝗲𝗮𝗱𝘆 𝘄𝗼𝗿𝗸𝘀, 𝘄𝗵𝘆 𝘂𝘀𝗲 𝗧𝗮𝗿𝗴𝗲𝘁 𝗖𝗮𝗽𝘁𝘂𝗿𝗲 𝗳𝗼𝗿 𝗽𝗮𝘁𝗵𝗼𝗴𝗲𝗻 𝗪𝗚𝗦? It's a question we occasionally hear from researchers. PCR-based amplicon sequencing remains an excellent approach for well-characterized targets. However, real-world clinical and environmental samples are often more challenging—pathogen abundance may be low, nucleic acids may be fragmented, and new variants continue to emerge. In these situations, sequencing performance depends not only on the sequencing platform, but also on the enrichment strategy. In our latest blog, we explore why Target Capture-based WGS has become an increasingly important approach for pathogen genomic surveillance, particularly when working with challenging samples. Read more: https://lnkd.in/gs5ysNae #pathogengenomics #wholegenomesequencing #targetcapture #targetenrichment #genomicsurveillance #ngs