BIA Separations Inc.

As biotherapeutics evolve, so do the challenges of purification and characterization.⬇️ 🔎From viral vectors and nucleic acids to lipid nanoparticles, exosomes, and phage-based systems, today's complex modalities require 𝙖𝙙𝙫𝙖𝙣𝙘𝙚𝙙 𝙨𝙚𝙥𝙖𝙧𝙖𝙩𝙞𝙤𝙣 𝙩𝙚𝙘𝙝𝙣𝙤𝙡𝙤𝙜𝙞𝙚𝙨. 💡Our monolithic chromatography solutions deliver efficient purification and high-resolution analytical characterization of large biomolecules – accelerating process development from early discovery through scale-up and manufacturing.

Separate LNP subpopulations by size and potency while improving process understanding.

𝗦𝘁𝗮𝗻𝗱𝗮𝗿𝗱 𝗽𝘂𝗿𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗺𝗲𝘁𝗵𝗼𝗱𝘀 𝗰𝗮𝗻'𝘁 𝗸𝗲𝗲𝗽 𝘂𝗽 𝘄𝗶𝘁𝗵 𝗻𝗲𝘅𝘁-𝗴𝗲𝗻 𝗺𝗼𝗱𝗮𝗹𝗶𝘁𝗶𝗲𝘀. 𝗢𝘂𝗿𝘀 𝗰𝗮𝗻! These monolithic chromatography platforms deliver high-resolution separation and deep process insight you need to scale with confidence. Achieve robust recovery across: ✔️Viral vectors (AAV, lentivirus) ✔️Nucleic acids (mRNA, pDNA) ✔️Lipid nanoparticles (LNPs) ✔️Exosomes ✔️Phage-based systems Built to support the next generation of therapeutic modalities.

𝗠𝗮𝘅𝗶𝗺𝗶𝘇𝗲 𝗿𝗲𝗰𝗼𝘃𝗲𝗿𝘆 𝗮𝗻𝗱 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗮𝗰𝗿𝗼𝘀𝘀 𝘆𝗼𝘂𝗿 𝗲𝗻𝘁𝗶𝗿𝗲 𝗽𝗶𝗽𝗲𝗹𝗶𝗻𝗲. Learn about advanced monolithic chromatography columns for fast, efficient production, purification, and analysis of large biomolecules used in gene therapies and vaccines.

See how CIM OH chromatography enables improved recovery and separation of functional particle populations.🔎 Compared to traditional techniques like TFF and dialysis, it delivers: ✔️Higher recoveries ✔️Enhanced stability ✔️Uniform size distribution ✔️Faster processing ✔️Reusable columns to reduce costs.

🔎The PATfix® LNP Switcher Platform goes beyond standard methods. By linking two monolithic columns in sequence, it delivers two critical readouts in a single run: ➡️CIMac® OH Column: Separates LNPs from free nucleic acids and determines particle size via MALS. ➡️CIMac® SDVB Column: Quantifies encapsulation efficiency, RNA purity, and RNA-lipid adducts. 💡Robust, high-recovery multi-cargo analysis for next-gen CAR-T, CRISPR, and vaccine quality control.