MedChemExpress LLC

⭐ MCE Webinar: Understanding and Targeting Immune Evasion Mechanisms in Small Cell Lung Cancer Small cell lung cancer (SCLC) is characterized by its highly aggressive phenotype, systemic metastases, and poor clinical outcome. Despite the benefits of adding immune checkpoint blockade to standard chemotherapy, tumors frequently evade immunosurveillance and develop therapy resistance. Dr. Lydia Meder and her group investigated molecular pathways underlying SCLC metastasis formation and were able to therapeutically block liver colonization. Moreover, they observed MHC-I loss in SCLC metastases, highlighting its role in immune evasion. They identified ERBB2 signaling as a suppressor of MHC-I and driver of immunomodulatory transcripts. Strikingly, combining ERBB2 inhibition with immune checkpoint blockade elicits profound T-cell responses in autochthonous murine SCLC, supporting further evaluation of this combination in future clinical trials in patients with SCLC. Join the discussion with Prof. Dr. Lydia Meder to learn more insights! 📆 November 4, 2026 (Thursday) 💡 What You Will Learn: ⭐Targeting molecular mechanisms of SCLC metastasis formation. ⭐Mechanisms of SCLC resistance to immune checkpoint blockade and immune evasion. ⭐Targeting ERBB2 signaling induces MHC-I expression and improves the response to immune checkpoint blockade. 📢 Featured Speaker: Prof. Dr. Lydia Meder • Professor for Cell Plasticity at the Tumor-Host-Interface, University of Erlangen-Nuremberg • Head of the Working Group on Preclinical Biobanking in the German Biobank Network https://lnkd.in/gjX5Gn-k #SmallCellLungCancer #SCLC #CancerResearch #Immunotherapy #Oncology #ImmuneEvasion #TranslationalMedicine #CancerImmunology #Webinar #MCEWebinar #MedChemExpress

⭐ MCE Webinar: Biocatalysis and Enzyme Engineering: Advancing Green Chemistry Through Enhanced Enzyme Stability Biocatalysis is a key green technology, yet poor operational stability often limits enzyme adoption in industry. Focusing on (S)-selective amine transaminases (ATAs), crucial for chiral amine synthesis, Prof. Per Berglund's team investigated their destabilization mechanisms and developed strategies to enhance their robustness. In his talk, Prof. Berglund addresses the impact of light-induced PLP cofactor degradation and presents an integrated engineering approach combining consensus sequence analysis, ancestral sequence reconstruction, and B-factor-guided proline engineering to improve enzyme performance. Join the discussion with Per Berglund, PhD to learn more insights! 📆 October 15, 2026 (Thursday) 💡 What You Will Learn: ⭐ Enzymes are valuable industrial catalysts for green chemistry applications. ⭐ The operational stability of enzymes can be engineered and enhanced. ⭐ Light-sensitive cofactors, such as pyridoxal 5′ - phosphate (PLP), play a crucial role in maintaining enzyme stability. 📢 Featured Speaker: Per Berglund, PhD • Professor of Biochemistry, KTH Royal Institute of Technology • Board Member, European Society of Applied Biocatalysis https://lnkd.in/gH8y3Phk #Biocatalysis #ProteinEngineering #EnzymeStability #GreenChemistry #Biotechnology #AmineTransaminases #webinar #MedChemExpress

⭐ Ready to master the next generation of 3D cell culture models? Organoids are revolutionizing disease modeling, precision medicine, toxicology, and high-throughput drug screening by mimicking native tissue structure and function like never before. But navigating the workflow-from matrix selection to functional analysis-can be complex. Join our upcoming webinar: Organoid Culture Essentials: From 3D Model Development to Functional Analysis! 📆 September 9, 2026 (Wednesday) 💡 What You Will Learn: ⭐ Core Principles & Advances: Key insights into organoid model types, organ-on-chip integration, and modern translational applications. ⭐ Essential Workflow Tools: Best practices for selecting basement membrane matrices, hydrogels, ready-to-use media, custom cytokines, and stem cell supplements. ⭐ Practical Functional Analysis: Streamlined downstream techniques for biomarker detection, viability/cytotoxicity assays, and high-resolution fluorescent imaging. 📢 Featured Speaker: Yisu Wang, PhD - Senior Product Manager, MedChemExpress with a strong background in biochemistry, pharmacology, and advanced imaging (including CARS microscopy and nanomedicine tracking across top research institutes like the Paterson Institute for Cancer Research and Istituto Italiano di Tecnologia), Dr. Wang brings deep technical and applied insights to elevate your research. Visit our MCE website to learn more: https://lnkd.in/gKezg-_f #Organoids #3DCellCulture #StemCellResearch #DrugDiscovery #Biotech #PrecisionMedicine #CellBiology #LifeSciences #MedChemExpress #Webinar

𝐌𝐞𝐝𝐂𝐡𝐞𝐦𝐄𝐱𝐩𝐫𝐞𝐬𝐬 (𝐌𝐂𝐄) – 𝐘𝐨𝐮𝐫 𝐓𝐫𝐮𝐬𝐭𝐞𝐝 𝐏𝐚𝐫𝐭𝐧𝐞𝐫 in Life Science Research 🗂️MCE provides 𝐡𝐢𝐠𝐡-𝐪𝐮𝐚𝐥𝐢𝐭𝐲, 𝐈𝐒𝐎-𝐜𝐞𝐫𝐭𝐢𝐟𝐢𝐞𝐝 research reagents for scientists worldwide: · 200+ Specialized 𝐂𝐨𝐦𝐩𝐨𝐮𝐧𝐝 𝐋𝐢𝐛𝐫𝐚𝐫𝐢𝐞𝐬 · 100,000+ 𝐈𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫𝐬 & 𝐀𝐠𝐨𝐧𝐢𝐬𝐭𝐬 · 14,000+ 𝐑𝐞𝐜𝐨𝐦𝐛𝐢𝐧𝐚𝐧𝐭 𝐏𝐫𝐨𝐭𝐞𝐢𝐧𝐬 · 2,000+ 𝐀𝐃𝐂-𝐫𝐞𝐥𝐚𝐭𝐞𝐝 𝐩𝐫𝐨𝐝𝐮𝐜𝐭𝐬 · 𝐎𝐧𝐞-𝐒𝐭𝐨𝐩 Compound Screening Platform · 𝐜𝐆𝐌𝐏 Small Molecules for cell therapy · 𝗘𝘅𝗽𝗲𝗿𝗶𝗲𝗻𝗰𝗲𝗱 𝗖𝘂𝘀𝘁𝗼𝗺 𝗦𝘆𝗻𝘁𝗵𝗲𝘀𝗶𝘀 from milligrams to kilograms of structurally diverse compounds ⚡With 𝟭𝟬 𝐰𝐨𝐫𝐥𝐝𝐰𝐢𝐝𝐞 𝐰𝐚𝐫𝐞𝐡𝐨𝐮𝐬𝐞𝐬 and 𝐥𝐢𝐭𝐞𝐫𝐚𝐭𝐮𝐫𝐞-𝐛𝐚𝐜𝐤𝐞𝐝 𝐯𝐚𝐥𝐢𝐝𝐚𝐭𝐢𝐨𝐧, MCE ensures fast, reliable delivery and consistent high quality. 🏆MCE is proud to achieve 𝐄𝐜𝐨𝐕𝐚𝐝𝐢𝐬 𝐆𝐨𝐥𝐝, ranking in the top 5% of sustainable and responsible companies worldwide. 𝐄𝐱𝐩𝐥𝐨𝐫𝐞 𝐦𝐨𝐫𝐞 𝐩𝐫𝐨𝐝𝐮𝐜𝐭𝐬: https://lnkd.in/eXGE3XQC

Hi %FIRSTNAME%, As your life science projects move from discovery to scale-up and commercialization, securing a reliable supply of high-quality bioactive molecules becomes crucial. Pre-sales consultation and post-sales technical support can help you select the right products, address project-specific requirements, and move forward with confidence. MedChemExpress (MCE) is a globally trusted partner offering a portfolio of 200,000+ bioactive molecules, including antibodies, screening libraries, recombinant proteins, ADCs, and more. MCE Industrial Bulk and Custom Product Services are tailored to your specific project requirements. Operating under strict ISO quality management systems and featuring cGMP-qualified manufacturing facilities, MCE guarantees batch-to-batch consistency with full analytical reporting, including NMR, LC/MS, HPLC, etc. To ensure a stable global supply chain, MCE has established a worldwide warehouse and logistics network, with Regional Business & Inventory Centers across Europe, the USA, and Asia-Pacific, etc. Empowered by demand forecasting, dynamic inventory linkage, and strong in-stock capacity, MCE delivers faster order fulfillment and efficient worldwide shipping. EU and UK clients benefit from dedicated localized support provided by the Local Business Centers and the Local Inventory Center, ensuring seamless and efficient operations. Reach out at [email protected] anytime for exclusive discounts on bulk and custom product services, or explore the Corporate Brochure to learn more about how MCE can support your research and development programs.

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